What does LCH stand for?

Langerhans cell histiocytosis (LCH) is a rare disorder that occurs when a child has too many of a certain type of cell called Langerhans cells. These cells normally reside in the skin and help fight infection and destroy foreign substances in the body.

What is LCH bone?

Langerhans cell histiocytosis (LCH) is a rare disease that originates from the uncontrolled proliferation and accumulation of bone marrow-derived immature myeloid dendritic cells.

What are LCH lesions?

Langerhans cell histiocytosis is a rare disorder that can damage tissue or cause lesions to form in one or more places in the body. Langerhans cell histiocytosis (LCH) is a rare disease that begins in LCH cells. LCH cells are a type of dendritic cell that normally helps the body fight infection.

What are the symptoms of LCH?

Symptoms of LCH can include:

• Pain, swelling or a lump in a bone that does not go away.
• Broken bone from a minor injury or for no obvious reason.
• Loose teeth (when not expected) or swollen gums.
• Ear infections, cysts in the ear or fluid draining from the ear.
• Skin rash, such as on the scalp or buttocks.

What is PLCH in lung disease?

Pulmonary Langerhans cell histiocytosis (PLCH), previously called eosinophilic granuloma of the lung, pulmonary Langerhans cell granulomatosis, and pulmonary histiocytosis X, is an uncommon cystic interstitial lung disease that primarily affects young adults [1-5]. It is caused by a disorder of myeloid dendritic cells.

Are Langerhans fatal?

Langerhans cell histiocytosis can cause damage to tissues and organs all over the body if it’s not treated. One example is pulmonary histiocytosis. This condition damages the lungs. Damage to the body can be so severe that the condition becomes fatal.

What causes LCH in adults?

Adult histiocyte disorders are rare diseases. The most common of these is Langerhans cell histiocytosis (LCH), which affects only a few hundred patients every year in the United States. LCH results from the body’s overproduction of immature histiocytes, which are a type of white blood immune cell.

What is Langerhans cell carcinoma (LCH)?

People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. [1]

Where is LCH found in the body?

LCH may be found in many areas of the body, including but not limited to the skin and nails, mouth, bones, lymph nodes, pituitary gland, and thyroid gland. When it is found in multiple areas of the body, it is known as multisystem disease.

How is Langerhans cell histiocytosis (LCH) staged?

There is no standard staging system for Langerhans cell histiocytosis (LCH). Treatment of LCH is based on where LCH cells are found in the body and whether the LCH is low risk or high risk. There is no standard staging system for Langerhans cell histiocytosis (LCH). The process used to find out the extent or spread of cancer is called staging.

What are the other names for LCH?

The various manifestations of LCH were previously known by a number of different names (histiocytosis-X, eosinophilic granuloma, Letterer-Siwe disease, Hand-Schüller-Christian syndrome, etc.).